What is GHRP-2?

Growth Hormone Releasing Peptide 2 (more commonly referred to as GHRP-2) is an hgH secretagogue. The peptide is sometimes referred to as Pralmorelin.

GHRP-2 stimulates the body’s ability to secrete Human Growth Hormone, which has been proven to reduce the body’s development of fat and to increase the development of lean body mass, or muscle.

This growth hormone releasing peptide is a non-natural super-analog of GHRP-6, which has the ability to dramatically stimulate the effect of growth hormone secretion. Additionally, it is a synthetic agonist of ghreline that binds with the growth hormone secretagogue receptor. The outcome includes increased calcium levels and an increased secretion of growth hormone.

Comparison of GHRP-2 and GHRP-6

GHRP-2 maintains maximum elevations of Growth Hormone over longer periods of time than GHRP-6. Some studies of GHRP-2 show that it increases IGF-1 levels (Insulin-like Growth Factor 1). While GHRP-6 studies show test subjects experience an increase in appetite, GHRP-2 seems to affect appetite much more than GHRP-6. Also, GHRP-2 can improve calcium levels in the body (which then plays a role in secreting other growth hormones). GHRP-6 is not known for increasing calcium levels.

GHRP-2 has a relatively short half life, the peak concentrations occurring at approximately 15 minutes after it has been taken, but no longer than 60 minutes after it has been administered.

Clinical Studies Related to GHRP-2

In clinical studies, it was found that GHRP-2 increased the pituitary gland’s ability to produce naturally occurring human growth hormone.

In studies where GHRP-2 was administered to monkeys with growth deficiencies and who were in catabolic states, it was found that this hormone stimulates the secretion of growth hormone, as well as induces the desire to eat. These results lie in the fact that Growth Hormone Releasing Peptide 2 (GHRP-2) has the ability to markedly stimulate the natural production of human growth hormone by the pituitary gland. On its own, this peptide has the ability to dramatically increase IGF-1 levels; however, when taken in conjunction with Growth Hormone Releasing Hormone (GHRH), the production of IGF-1 levels were even greater. Additionally, the function of the hypothalamus was found to increase.

In studies conducted on arthritic rats, it was determined that GHRP-2 had an anti-inflammatory effect, which resulted from the peptides ability to be mediated by ghrelin receptors directly onto the immune cells.

Medical Use of GHRP-2

This peptide can be prescribed to those who have growth hormone deficiency and will be medically supervised.  GHRP-2 is generally taken over a 16 month period with an injection dosage ranging between 1 to 6 times a day, starting with a 25-50 mcg injection. Just like in studies involving monkeys, it has been found that this peptide has the ability to increase the pituitary gland’s ability to produce endogenous growth hormone, which stimulates the appetite.  Potential benefits of GHRP-2 therapy are being studied for the future medical use for:

  • Reduced belly fat
  • Increased energy levels and vitality
  • Increased endurance
  • Improved sex drive
  • Advanced wound healing
  • Improved elasticity of the skin, creating a younger looking appearance
  • Enhance sleep
  • Improved vision
  • Increases the synthesis of protein
  • Aids in the function of the pancreatic islets

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