Benefits and Side Effects of S4 Andarine and SR9009

For improve muscle strength and stamina, researchers have turned to S4 and SR9009. Countless studies have been conducted in various populations to investigate the rewarding effects of these SARMS and how they improve overall health and aging.

About S4 (Andarine)

S4 is a SARM, selective androgen receptor modulator, that targets specific tissue for maximum productivity. The therapeutic compounds is used for medical research only to discover its many benefits for improving muscle mass, which is caused by muscle-wasting diseases, and bone density. SARMS are highly desired because they don’t have the same effects as anabolic agents like steroids that cause increased facial hair growth, back hair, voice changes, and breasts in men.

 

Benefits of S4 (Andarine)

S4 is for medical use and research only. Researchers have investigated the many benefits of S4 as a therapy to improve muscle health and bone density. The research targeted not just the muscle and bone itself, but the overall body pathways that control muscles and bone (Girgis, et. al.) Reported benefits of selective androgen receptor modules (SARMs) such as S4 (Andarine) when used for medical research only are:

  • Improved lean muscle mass (when treating for muscle wasting disease)
  • Increased bone density
  • Increased strength in men
  • No side-effects experienced as with anabolic steroids
  • Targeted treatments for specific needs and muscle-building demands
  • Preservation of bone mass
  • Improved body composition
  • Improved spermatogenesis (Chen, et. al.)

 

Side Effects and Risks of S4

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The Inside Scoop About RAD 140 SARM

Exactly how rad is RAD 140? In research trials, this SARM acts a lot like an anabolic steroid (testosterone) and pro-hormone. In lab studies with animals, RAD 140 has been shown to:

  • Enhance speed
  • Increase stamina
  • Increase endurance
  • Build muscle faster

In testing, RAD 140 has a higher anabolic effect than testosterone, while limiting the number of negative effects the test subject experienced. Testosterone typically causes a number of undesirable side effects along with the benefits, and RAD 140 test results are showing fewer side effects but the same positive results for muscle building and endurance. In some studies, hair growth and an increase in hormones in the body were found after giving lab rats RAD 140.

What’s a SARM?

A SARM is an androgen receptor ligand, which means it binds to the androgen receptor in your body. Research with SARMs started in the 1940s when the testosterone molecule was modified for use to decrease obesity and ensure bone health was at optimum levels. SARMs were created as a way to fight diseases that cause muscle wasting without causing the side effects associated with steroid usage.

Potential Uses for RAD 140

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Rare YK11 Compound is a SARM

What are SARMs? Selective Androgen Receptor Modulators = SARMs. Androgens are hormones that act as molecules or ions to bind to the cellular androgen receptors and the receptors are involved in transmitting complex signals that result in greater expressions of specific genes. When bodybuilders, athletes, or people with muscle wasting diseases ranging from cancer to osteoporosis partake in anabolic steroids to increase their muscles, the binding of androgen hormones to the androgen receptor is what results in more muscle and decreased body fat. Drugs and substances that block or stimulate the androgen receptor are called “selective receptor modulators”.

YK11 is a rate compound that was first studied by researcher Yuichiro Kanno of Toho University in 2011. Initial studies confirmed that the compound is in fact a SARM. YK11 attaches to the androgen receptor. Kanno’s published report of the results from this study exposed that muscle cells exposed to YK11 create more anabolic effects at 500 nanomoles than when exposed to DHT and other similar compounds at the same amount.

Chemical Composition of YK11

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Research Chemical: YK-11

YK-11 is researched heavily in Japan by researchers and chemists determined to find out what the potential benefits of the SARM may be for future human use in pharmaceutical products. Initial studies have discovered that YK11 is a potent SARM in terms of creating anabolic effects in the body that lead to muscle enhancement while inhibiting myostatin effects. The potential for YK11 to be used in the treatment of diseases causing muscle waste is something researchers are considering further.

YK11 is Similar to Testosterone

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What is Bacteriostatic Water

Bacteriostatic water is a highly purified, sterilized water used to dissolve medications or dilute medications to the appropriate consistency for injection. Bacteriostatic water (BW) is a sterilized water that contains .9% benzyl alcohol and has a pH of about 5.7. The alcohol in the water helps prevent the growth of most forms of bacteria which makes it ideal for diluting any drug that will be administered by intramuscular, intravenous, or subcutaneous injection.

Bacteriostatic water is not used for neonatal medications because it contains benzyl alcohol, which is toxic, and can cause blood pressure changes in babies under four weeks of age. BW for injection is provided in unpressurized, 30 mL plastic vials, specially formulated from polyolefin. It is a copolymer of propylene and ethylene, and is considered safe plastic according to USP biological standards for plastic containers and the animal testing which took place to confirm its safety. The plastic container for bacteriostatic water doesn’t require a vapor barrier to maintain the proper volume.

Most sources recommend that bacteriostatic water is used within 28 days of opening the vial. The preservatives will allow it to keep safely for up to 30 days.

Potential Side Effects of Bacteriostatic Water

There are not many side effects associated with using bacteriostatic water. When there are side effects, it’s probably more related to the drug that is dissolved in the bacteriostatic water, or some sort of contamination of the water prior to use.
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What Are Peptides?

Peptides are found in living organisms and are made of short chains of amino acid molecules, linked together by amide bonds. Dipeptides consist of two amino acids linked by a single amide bond. Tripeptides are three amino acids linked together with amide bonds, while polypeptides are long chains of peptides linked together.

Peptides and proteins are usually distinguished based on their size. Peptides have 50 or fewer amino acids, while proteins are made up of one or more polypeptides. The size boundaries are not absolute, however, and there is some overlap and discrepancies involved in whether or not something is considered a peptide or a protein. Some long peptides are called proteins, while some smaller proteins can be considered peptides.

Peptides and Body Functions

All life requires peptides in order to exist. Peptides occur naturally within every living cell of every living being and perform a variety of essential functions. Peptides produce enzymes that allow bodies to break down foreign substances; hormones to control growth and sexual development; and create antibiotics for the immune system.

Peptide Drug Research

Research of peptides is required for the development of new medications. Research of peptides may be performed on naturally occurring peptides, or on synthetically produced peptides. When research peptides are developed synthetically, they can help patients with immune functionality and the production of hormones. Synthetic peptides can positively impact the function of your body’s creation of natural peptides. Many scientists and researchers study the effects of various peptides on test subjects in labs to discover new possibilities for treating ailments and improving the quality of life.

Common Research Peptides

There are a number of peptides that are commonly researched in laboratories with rats or primates, including but not limited to:
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How to Use GHRP-6 for Research

The hexapeptide GHRP-6, is a Growth Hormone Releasing Peptide, and consists of a chain of six amino acids. GHRP-6 is in the same category of peptides as GHRP-2, Ipamorelin, and Hexarelin. It is a man-made secretagogue, which means it is a substance that causes the secretion of another substance. Secretagogues are used widely in clinical activities and research. GHRP-6 is also considered a protein hormone, and has been shown cause a reaction with the ghrelin receptor, which communicates with the pituitary gland to begin releasing growth hormone.

GHRP-6 Research Results

GHRP-6 is a fairly new compound that has not been legally approved for use over the counter or for medical purposes yet. The hexapeptide is undergoing medical trials to determine the effects of GHRP-6 and whether or not it is useful for health. Some of the studies are testing saturation levels for dosage and usage. Currently, studies show the peptide has variations in its half-life duration that ranges between a quarter hour to an hour, with the increase in GH levels maximizing about half an hour after use.

Historically, scientists and researchers have chosen to study GHRP-6 for its ability to produce growth hormone, which in turn can reduce fat and increase lean body mass. When the GH levels are increased, IGF-1 will also increase. The protein has been shown in studies of lab rats to decrease weight, increase energy, help heal physical injuries, and reduce inflammation. But more recently, research has expanded as it was discovered the peptide has more properties and potential benefits than just the ability to increase GH levels. More research needs to take place to learn about the other properties of this peptide and what benefits it may offer in the future.

Recent studies have begun testing the neuroprotective effects of GHRP-6. It is thought that the peptide assists in removing faulty cells from the organism through the caspase-independent pathway. In the studies, the glutamate-induced cell death was altered by GHRP-6, which shows the neuroprotectivity of the peptide as it blocks the caspase-independent cell death.

Chemical Information for GHRP-6

GHRP-6 has a molecular formula of C46H56N12O6. Its systematic name is L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-Lysinamide.
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Functionality and Benefits of Igf-1 des

Igf-1 des is a peptide secreted by the liver and consists of 67 amino acids. Igf-1 des stimulates hormones as it is a highly anabolic structure. In living organisms, Igf-1 des offers a number of benefits and is responsible for creating hyperplasia (or hypergensis). It is important to note that Igf-1 des can also cause negative side effects, which we will also discuss in this article.

What Does Igf-1 des Do?

Igf-1 creates hyperplasia, which is a process that regulates the growth of cells. The need for increased cells come as a result of any of the following cases:

• Response to chronic inflammation – cells multiply to help the body reduce inflammation.
• Response to hormonal dysfunction – cells multiply to fight off conditions that could cause improper functioning of the endocrine system.
• Compensate for skin loss – cells multiply to create a new layer of skin.
• Compensate for cellular loss – cells multiple to replace cells lost due to damage and disease.

Igf-1 des Scientific Research

Scientific research involving Igf-1 des indicates the peptide is also capable of influencing neurological growth, maintain nerve cell function, and promote nerve growth. It’s ability to create hyperplasia leads scientists to use animals for researching the ability of Igf-1 des in relation to growing cells and the development of tissue. Studies show that Igf-1 des has the capability to influence the neuronal structure and functions of the brain, and continuing animal studies are watching the peptide’s effects on muscular and skeletal growth.
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How to Properly Store Peptides

When you receive your peptides you will want to make sure you know how to properly store peptides to prolong their lifespan and ensure the stability of your product. While peptides can remain stable at room temperature for a few days to a couple weeks, for the best preservation, it is recommended that you store your peptides in the refrigerator at 4°C or colder, inside an airtight container such as a sealed freezer bag, and out of direct, bright, light.

Your airtight container (or vial) should be clear and resistant to chemical breakdown. Choose a size that is appropriate for the amount of peptide you will be storing, and make sure the container is strong enough to withstand being moved around in storage or when taken out for use. Most researchers select glass containers, although some forms of plastic is suitable for storing peptides.

Keep Your Peptides Dry

If your peptides are contaminated by moisture the long term stability of solid peptides will be greatly decreased. When you use some of the peptide, take the storage container from your refrigerator and allow it to come to room temperature before you open the container. Weigh the required quantity of peptide for your experiment quickly.  This reduces the amount of moisture that comes from opening the cold surface of the container and exposing the contents to the warmer air of the room.

After you have removed the desired quantity of your peptide, reseal your vial tightly, place inside a sealed freezer bag, and return to the refrigerator or other dry, cold storage.

Storage of Peptide Sequences With C, M, or W

Peptide sequences containing C, M, or W are affected negatively by air oxidation. Remove the air from the vial and replace with a blanket of argon or nitrogen to prolong the lifespan of these peptides and ensure their reliability for your research purposes.
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How to Mix Peptides

Wondering how to mix peptides? Before getting started, make sure you have the following four items: peptide vial, 1ml insulin syringe, Bacteriostatic Water, and alcohol swabs.

Insulin syringes are available in multiple sizes, including .3ml, .5ml, and 1ml. If you try to use a smaller syringe (.3ml or .5ml) you will need to repeat the process of filling the syringe multiple times. It is must easier and efficient to use a 1ml insulin syringe.

Here’s what you need to know about the process of mixing peptides:

Keep Your Powder Peptide Vials Cold

Put your powder peptide vials in the refrigerator for storage so they stay cold. The freezer may damage the peptide. Store your mixed solution in the refrigerator as well as it will prolong its lifespan for weeks or months, depending on the peptide.

Swab Vial Top

Before drawing out the dose, swab the top of the vial with an alcohol swab and wait about one minute after swabbing. You don’t want any contaminates changing the results of your research.

Vent Air

When mixing the solution into your peptide vial, twist off the pin top while still inside the vial for a split second, to vent out air pressure, and then pull out the pin top.
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How to Tell if you are Buying Your Research Peptides From a Reputable Company

Research chemicals are growing in popularity as people like to experiment with peptides in their home or work labs. They should be handled by licensed, expert professionals. Understand that peptides are not cosmetics or a food, and they are mostly used for laboratory experiments and in Vito testing.

You can buy research peptides online from many peptide suppliers, but when it comes to buying research peptides it’s important to know you’re buying from a reputable company. You need to know that you can repeat your tests and experiments to get reliable results each and every time.  The quality and purity of your peptide supplies matter to the accuracy of your experiments.

Here is how to tell if you are buying your research peptides from a reputable company:

The Company Has Purity Results Available

Reputable research peptide companies test their products to guarantee the grade of peptide their customers receive.  The testing should be completed on each new batch of peptides received, so they ensure customers are getting the grade of peptides ordered. A reputable company will supply test results for you if you ask for them, and some will publish the results right on their website. A certificate of purity results of the company’s own lab testing should be available to anyone who asks about the quality of the peptides before making a purchase.

You’re Buying From the USA

When it comes to research peptides, the United States has higher purity and safety standards than most any other country in the world. If you want to ensure the research testing you perform is both safe and accurate, make sure you buy from a United States peptide supplier.

Reputable Peptide Suppliers Only Sell for Research Purposes

When reviewing the website of a peptide supplier, you should see a notation that the company only sells peptides for research purposes and that the products are not intended for human consumption.
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