Triptorelin is a gonadotropin-releasing hormone agonist (GnRH agonist). It’s used as an acetate. It is a man-made form of a hormone responsible for regulating many body processes. It’s a decapeptide that causes constant stimulation in the pituitary gland, which decreases the secretion of gonadotropins: luteinizing hormone (LH) and follicle stimulating hormone (FSH). Triptorelin overstimulates the body’s production of hormones and then it causes production to shut down entirely for a short period of time. In medicine, it is used in the treatment of prostate cancer through an injection, and marketed under the brand names Diphereline, Decapeptyl, and Gonapeptyl.  It treats the symptoms of prostate cancer, not the cancer itself.  When used for treating prostate cancer, patients sometimes indicate an increase or worsening symptoms for the first few weeks as Triptorelin increases testosterone levels, but most patients report symptom relief after the first dose.

Clinical Studies of Triptorelin

A multi-center clinical trial of triptorelin was organized to evaluate the use of triptorelin and adverse effects of using triptorelin injections monthly for the treatment of endometriosis. Endometriosis is a chronic disease that affects over 6 million females in the United States.  Endometriosis is when the tissues lining the uterus grow in other areas outside of the uterus, in the abdomen or on the ovaries, or on the fallopian tubes or the area between the vagina and rectum, for example. Less commonly, the misplaced tissue can growth in the lung, arm or other locations.
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Though research in the United States has almost entirely ceased, Melanotan is still making its rounds in the medical field as a hopeful solution to a variety of ailments. If you’re interested in getting involved in the research of Melanotan but don’t know where to start, we’ve put together a short background on the chemical and where it stands today.

What is Melanotan?

Melanotan, also known as Melanotan-II, is a synthetic (lab-made) chemical similar to a naturally occurring hormone found in people. It is essentially a synthetic version of an alpha-melanocyte stimulating hormone(a-MSH). It is not the same as the sleep aid melatonin.

First synthesized in the early 1990s, though research first began all the way back in the 1960s, by the department of pharmacology at the University of Arizona (UAC) in an effort to battle skin cancer and hopefully reduce the harm caused by harmful ultraviolet light from the sun and other sources.

What is Melanotan Used for?

Used to promote the bodies pigment tissue (melanin) to halt cancer malignancy by strengthening the bodies melanin production without exposure to the sun and possibly help increase the quality of life for those who suffer from albinism by increasing the skin’s resilience to sunburn and cancer. In the simplest of terms, it helps people tan better, offering protection from the sun’s harmful rays.
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Understanding Albuterol

Albuterol is a catalog chemical also called Salbutamol. Scientific research has discovered the chief function of Albuterol is to influence the beta adrenergic receptors of the cell membrane. This influence results in the rapid relaxation and smoothing out of muscles. Animal test subjects reacted to albuterol by releasing insulin, bronchial passages dilated, and the blood vessels in the muscles and liver widened. Subjects of the female variety showed uterine muscle relaxation during testing.

Effects of Albuterol on Breathing

Albuterol in relation to breathing activities show beneficial effects on in animal testing subjects. The presence of Albuterol in subjects with breathing issues have shown to be effective in relaxing the bronchial walls. Testing shows Albuterol has been linked to effective treatment of obstructive lung conditions including chronic obstructive pulmonary disease, more commonly known as COPD. This catalog chemical is regarded for its fast-acting capabilities to aid with better breathing.
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Tesamorelin, also known as Egrifta on the market, is a prescription only, artificial hormone normally produced and released from the hypothalamus gland of the brain that reduces excess body fat of the stomach in humans diagnosed with the human immunodeficiency virus (HIV). The medication falls into the group of medication known as human growth hormone-releasing factor (GRF) analogs, due to the fact that it stimulates the synthesis and release of growth hormones that help break down fatty tissue.

Tesamorelin Prescription

Since Tesamorelin is available by prescription only, chances are a qualified medical professional has already decided that Tesamorelin is a good fit. But, it is always a good idea to do your own research beforehand. This short list will help you determine the potential benefits and risks of a tesamorelin prescription:

• • Age – Tesamorelin has been heavily researched in adults 18 to about 60 years of age. This gives a limited scope on interactions with children and older people, take age into consideration.
  • Allergies – When speaking with your physician about any prescription, allergies should be at the top of the list, as synthetic hormones may trigger specific allergens.
  • Drug interactions – As with allergies, you should make your prescriber aware of any medication you currently take, as unwanted and severe interactions may occur.
  • Side effects – As with any prescription, there are side-effects that you’ll want to consider. Do the effects outweigh the outcome? Here are the common side effects that will help you decide: joint pain, arm and leg pain, and possible swelling of the legs.

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Anastrozole is a medication that blocks estrogen production. It is part of the nonsteroidal aromatase inhibitor drug group. Doctors prescribe it for breast cancer treatment, particularly in post-menopausal women with localized breast cancer, or will prescribe to individuals who are at high risk for getting breast cancer for prevention purposes. Anastrozole reduces estrogen hormone levels which in turn will slow the growth of tumors and shrink tumors.

The majority of women with breast cancer are considered ER positive (oestrogen receptor positive), and their cancer cells require estrogen to survive and continue to grow. Before a women reaches menopause, the oestrogen is produced in her ovaries. After menopause, the production of oestrogen in the ovaries decreases drastically and aromatase is used in the body to convert androgens produced by adrenal glands into oestrogen.

Scientific research and clinical trials discovered that aromatase inhibiting drugs could reduce oestrogen levels in postmenopausal women and thus treat (and kill the cells causing) breast cancer.
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What is it?

Thymosin Alpha 1, often characterized as Thymosin α1, is a peptide fragment found in prothymosin alpha.  Prothymosin alpha is a protein found in humans and other mammals.  So far, we understand that the main function of this particular protein and its peptide fragments are to initiate the restoration of immune systems in mammals that have poorly function thymus glands.  Both in animals and in humans, it’s been proven to enhance immunity but a considerable amount.

In humans and our monkey-family cousins, the thymus is a special lymphoid organ that rests between our hearts and sternums.  Its main function is to enhance our immune systems by creating T cells from hematopoietic progenitor cells.  Think of the thymus as your own personal center for disease control.  For various reasons, the center of disease control may lose power or struggle to come up with the antibodies needed to fight off disease.  That’s where the Thymosin Alpha 1 can come in and help act as a substitute for your body’s CDC.
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Growth Hormone Releasing Peptide 2 (more commonly referred to as GHRP-2) is an hgH secretagogue. The peptide is sometimes referred to as Pralmorelin.

GHRP-2 stimulates the body’s ability to secrete Human Growth Hormone, which has been proven to reduce the body’s development of fat and to increase the development of lean body mass, or muscle.

This growth hormone releasing peptide is a non-natural super-analog of GHRP-6, which has the ability to dramatically stimulate the effect of growth hormone secretion. Additionally, it is a synthetic agonist of ghreline that binds with the growth hormone secretagogue receptor. The outcome includes increased calcium levels and an increased secretion of growth hormone.

Comparison of GHRP-2 and GHRP-6

GHRP-2 maintains maximum elevations of Growth Hormone over longer periods of time than GHRP-6. Some studies of GHRP-2 show that it increases IGF-1 levels (Insulin-like Growth Factor 1). While GHRP-6 studies show test subjects experience an increase in appetite, GHRP-2 seems to affect appetite much more than GHRP-6. Also, GHRP-2 can improve calcium levels in the body (which then plays a role in secreting other growth hormones). GHRP-6 is not known for increasing calcium levels.
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Ketotifen fumarate is an antihistamine that is most commonly used to treat allergic conjunctivitis, which causes irritated eyes from allergies to everyday nuisances, including pollen, dust and animals. It is marketed as a salt with fumaric acid in its ophthalmic design. Ketotifen fumarate is also available in an oral form, which is used to combat Anaphylaxis, asthma attacks and the majority of mast cell, allergic conditions. Fumaric acid can be found in Iceland moss, bolete mushrooms, fumitory and lichen and was first created from succinic acid.

When ketotifen fumarate is properly administered in its eye drop form, it begins to almost immediately work to prevent irritation and/or eye itchiness that comes with many seasonal allergies. Within minutes, the user will feel relief. The common brand name for the ophthalmic form of ketotifen fumarate is Zadiator, which is available in generic form. Dosage for children over age 3 and for adults is 1 drop in the bothered eye or eyes, every 8-12 hours, no more than 2 times daily, or as instructed by a physician. It should be used at the same time every day. Hands should always be washed before applying to the eye. Before wearing contact lenses while using this medication, check with your doctor and always remove them before applying the drops. Ketotifen fumarate should not be used to treat eyes that are irritated from wearing contact lenses.
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Exemestane is a medication regularly used to treat and prevent certain types of breast cancer in women who have stopped menstruating due to menopause.  It is an oral medication that works to decrease the amount of estrogen that the body makes and helps to slow or reverse the growth of some types of breast cancers.  It is typically used to treat hormone-receptor-positive breast cancer. Some cancers grow and spread faster by the amount of estrogen that is produced in the body. This medication works to lower estrogen levels and may slow down the growth of some tumors that form in the breast. It is also often used to treat women who have been through cancer treatments including radiation or surgery, or who have tried other cancer medications that have not been effective. The brand name for exemestane is Aromasin.

Exemestane is not typically used to treat women of childbearing age and is not a safe choice for everyone, even if they have the same illness. It is possible that potential users may have to have a pregnancy test that comes back negative before starting this medication.  Exemestane can cause birth defects. The drug should not be taken by pregnant women or those who are still menstruating and have not gone through menopause. Your medical provider will know the best course of treatment for your circumstance.

In those unusual cases that do exist that exemestane is used to treat women who are not yet past menopause, birth control should be used during the use of exemestane and for a least one month after the last dose of the medication.  It is important to share your information with your doctor before you consider this medication for breast cancer treatment, and also if you do become pregnant. It is unknown if exemestane passes into breast milk, so it is not advised to breastfeed while on exemestane. Exemestane can pass through body fluids such as urine, vomit, and feces. Anyone caring for someone using this medication should practice universal precautions and clean soiled items separately.
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LGD-4033 is a non-steroidal selective androgen receptor modulator (SARM) that is unique in the world of SARMs as it is the only SARM to have been researched in clinical trials for use by healthy, human men. LGD-4033 research studies are trying to verify whether or not LGD-4033 would be safe for use by men, particularly athletes looking to increase the size of their muscle and gain improved athletic performance abilities. The world of professional sports is no stranger to the use of SARMs, including LGD-4033. Joakim Noah from the Knicks basketball team was once suspended for twenty games due to having LGD-4033 in his system, as it is an unapproved health supplement under the rules of the NBA.

What Do SARMs Do?

Selective androgen receptor modulators act on the androgen receptor gene. When activated, it will bind to androgenic hormones like testosterone, DHEA, and DHT. The androgen receptor has a few responsibilities in the bodies of both males and females. In males, androgens are responsible for the testosterone hormone that promotes masculinity, including muscle growth and a healthy sex drive. In females, the androgen receptor regulates the growth of hair and sex drive, and can be converted to estrogen in the ovaries.
LGD-4033 is a SARM with the possibility for treating hormone related concerns such as loss of muscle and aging-related diseases. In the past, these diseases and muscle wasting conditions would be treated with testosterone, which will improve muscle wasting, some cancer conditions, and aging-related diseases – but it also affects brain activity and hormones with unwanted side effects. SARMs like LGD-4033 may be able to deliver the anabolic benefits of testosterone without the hormonal side effects since SARMS are selective in their binding nature whereas testosterone is not.
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