What is it?

Thymosin Alpha 1, often characterized as Thymosin α1, is a peptide fragment found in prothymosin alpha.  Prothymosin alpha is a protein found in humans and other mammals.  So far, we understand that the main function of this particular protein and its peptide fragments are to initiate the restoration of immune systems in mammals that have poorly function thymus glands.  Both in animals and in humans, it’s been proven to enhance immunity but a considerable amount.

In humans and our monkey-family cousins, the thymus is a special lymphoid organ that rests between our hearts and sternums.  Its main function is to enhance our immune systems by creating T cells from hematopoietic progenitor cells.  Think of the thymus as your own personal center for disease control.  For various reasons, the center of disease control may lose power or struggle to come up with the antibodies needed to fight off disease.  That’s where the Thymosin Alpha 1 can come in and help act as a substitute for your body’s CDC.
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Growth Hormone Releasing Peptide 2 (more commonly referred to as GHRP-2) is an hgH secretagogue. The peptide is sometimes referred to as Pralmorelin.

GHRP-2 stimulates the body’s ability to secrete Human Growth Hormone, which has been proven to reduce the body’s development of fat and to increase the development of lean body mass, or muscle.

This growth hormone releasing peptide is a non-natural super-analog of GHRP-6, which has the ability to dramatically stimulate the effect of growth hormone secretion. Additionally, it is a synthetic agonist of ghreline that binds with the growth hormone secretagogue receptor. The outcome includes increased calcium levels and an increased secretion of growth hormone.

Comparison of GHRP-2 and GHRP-6

GHRP-2 maintains maximum elevations of Growth Hormone over longer periods of time than GHRP-6. Some studies of GHRP-2 show that it increases IGF-1 levels (Insulin-like Growth Factor 1). While GHRP-6 studies show test subjects experience an increase in appetite, GHRP-2 seems to affect appetite much more than GHRP-6. Also, GHRP-2 can improve calcium levels in the body (which then plays a role in secreting other growth hormones). GHRP-6 is not known for increasing calcium levels.
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Ketotifen fumarate is an antihistamine that is most commonly used to treat allergic conjunctivitis, which causes irritated eyes from allergies to everyday nuisances, including pollen, dust and animals. It is marketed as a salt with fumaric acid in its ophthalmic design. Ketotifen fumarate is also available in an oral form, which is used to combat Anaphylaxis, asthma attacks and the majority of mast cell, allergic conditions. Fumaric acid can be found in Iceland moss, bolete mushrooms, fumitory and lichen and was first created from succinic acid.

When ketotifen fumarate is properly administered in its eye drop form, it begins to almost immediately work to prevent irritation and/or eye itchiness that comes with many seasonal allergies. Within minutes, the user will feel relief. The common brand name for the ophthalmic form of ketotifen fumarate is Zadiator, which is available in generic form. Dosage for children over age 3 and for adults is 1 drop in the bothered eye or eyes, every 8-12 hours, no more than 2 times daily, or as instructed by a physician. It should be used at the same time every day. Hands should always be washed before applying to the eye. Before wearing contact lenses while using this medication, check with your doctor and always remove them before applying the drops. Ketotifen fumarate should not be used to treat eyes that are irritated from wearing contact lenses.
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Exemestane is a medication regularly used to treat and prevent certain types of breast cancer in women who have stopped menstruating due to menopause.  It is an oral medication that works to decrease the amount of estrogen that the body makes and helps to slow or reverse the growth of some types of breast cancers.  It is typically used to treat hormone-receptor-positive breast cancer. Some cancers grow and spread faster by the amount of estrogen that is produced in the body. This medication works to lower estrogen levels and may slow down the growth of some tumors that form in the breast. It is also often used to treat women who have been through cancer treatments including radiation or surgery, or who have tried other cancer medications that have not been effective. The brand name for exemestane is Aromasin.

Exemestane is not typically used to treat women of childbearing age and is not a safe choice for everyone, even if they have the same illness. It is possible that potential users may have to have a pregnancy test that comes back negative before starting this medication.  Exemestane can cause birth defects. The drug should not be taken by pregnant women or those who are still menstruating and have not gone through menopause. Your medical provider will know the best course of treatment for your circumstance.

In those unusual cases that do exist that exemestane is used to treat women who are not yet past menopause, birth control should be used during the use of exemestane and for a least one month after the last dose of the medication.  It is important to share your information with your doctor before you consider this medication for breast cancer treatment, and also if you do become pregnant. It is unknown if exemestane passes into breast milk, so it is not advised to breastfeed while on exemestane. Exemestane can pass through body fluids such as urine, vomit, and feces. Anyone caring for someone using this medication should practice universal precautions and clean soiled items separately.
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LGD-4033 is a non-steroidal selective androgen receptor modulator (SARM) that is unique in the world of SARMs as it is the only SARM to have been researched in clinical trials for use by healthy, human men. LGD-4033 research studies are trying to verify whether or not LGD-4033 would be safe for use by men, particularly athletes looking to increase the size of their muscle and gain improved athletic performance abilities. The world of professional sports is no stranger to the use of SARMs, including LGD-4033. Joakim Noah from the Knicks basketball team was once suspended for twenty games due to having LGD-4033 in his system, as it is an unapproved health supplement under the rules of the NBA.

What Do SARMs Do?

Selective androgen receptor modulators act on the androgen receptor gene. When activated, it will bind to androgenic hormones like testosterone, DHEA, and DHT. The androgen receptor has a few responsibilities in the bodies of both males and females. In males, androgens are responsible for the testosterone hormone that promotes masculinity, including muscle growth and a healthy sex drive. In females, the androgen receptor regulates the growth of hair and sex drive, and can be converted to estrogen in the ovaries.
LGD-4033 is a SARM with the possibility for treating hormone related concerns such as loss of muscle and aging-related diseases. In the past, these diseases and muscle wasting conditions would be treated with testosterone, which will improve muscle wasting, some cancer conditions, and aging-related diseases – but it also affects brain activity and hormones with unwanted side effects. SARMs like LGD-4033 may be able to deliver the anabolic benefits of testosterone without the hormonal side effects since SARMS are selective in their binding nature whereas testosterone is not.
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Clenbuterol is a drug commonly used for those who suffer from breathing disorders. Also marketed as Ventipulmin, Dilaterol and Spiropent, clenbuterol is a sympathomimetic amine that acts as a bronchodilator and decongestant. The most common form it comes in is clenbuterol hydrochloride, which is a hydrochloride salt. Clenbuterol has similar structural and pharmaceutical properties as salbutamol and epinephrine. It is a β₂ agonist with effects that are longer lasting and more potent as a stimulant and thermogenic drug.

Clenbuterol is often used by patients with chronic breathing disorders, such as asthma and obstructive pulmonary disease, as a bronchodilator to make it easier to breathe. It creates a heightened aerobic capacity, an increase in blood pressure and central nervous system stimulation as well as better oxygen transportation. The rate at which body fat is metabolized increases with clenbuterol as well as basal metabolic rate. It is most often used because of its properties of being a smooth muscle-relaxant and as a tocolytic and bronchodilator. Clenbuterol works by binding to muscle cells and stimulating muscle protein synthesis.

Because it s used as a bronchodilator for chronic breathing disease treatment, clenbuterol is useful in reducing exercise-induced asthma. Studies from the 1980’s revealed that it guards against exercise-induced asthma and does not cause adverse effects on the body’s cardiovascular system. However, it has not been found to enhance cardiovascular performance in heathy people. It has surprisingly been shown to lower exercise duration and endurance, contrary to popular belief.
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Two branches of dermatological research lead to the discovery of Matrixyl. One branch was researching substances that would help skin wounds heal faster, and the other was a study for the underlying causes of wrinkles in an effort to find a way to prevent or erase them. The Matrixyl synthetic peptide is commonly used in anti-aging cosmetic products designed to reduce or prevent wrinkles and maintain a youthful appearance to the skin. Peptides are protein fragments that interact and affect cells. When used in cosmetics, Matrixyl is often combined with Argireline. The peptide Argireline reduces the appearance of wrinkles by paralyzing the muscles of the face a bit, so there are fewer expression lines, while Matrixyl works to promote the growth of collagen, elastin, and glucosaminoglycans.

Matrixyl Scientific Information

Molecular Formula: C39H75N7O10

Molecular Sequence: Pal-Lys-Thr-Thr-Ser-OH or Pal-KTTS-OH

Also known as: almitoyl pentapeptide-3

Because Matrixyl is a molecule that is identical to another molecule but has different atomic components, it is considered an isomer. The active element found within Matrixyl is another peptide called Micro-collagen. Matrixyl is also a lipopeptide, which is a fatty acid mixed with amino acids.
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Snap 8 is an octapeptide strand of eight amino acids that is studied for its potential to prevent the formation of wrinkles and lines on faces. The peptide is created by the cosmetic company Kinerase, and is considered 30% more effective than Argireline.

Who is Kinerase?

Kinerase is a cosmetic line of products that are designed to make skin look and feel younger and healthier. Kinerase products contain both over-the-counter and cosmetic ingredients, including Snap 8, and do not require a prescription to obtain.

What is Argireline?

Snap 8 is an elongation of the hexapeptide, acetyl hexapeptide-3, otherwise known as Argireline. It’s been nicknamed the “anti-wrinkle peptide”. Argireline is a peptide that prevents the formation of wrinkles around the eyes, brow, nose, and mouth – all of the areas of the face that allow us to make expressions and display emotion. How does it prevent wrinkles and lines? Argireline inhibits muscle movement, and has earned the name “Botox in a jar” as a result – but Botox and Argireline work differently.
Botox boosts collagen and helps repair skin to reduce lines and wrinkles. Argireline and Snap 8 work by mimicking the proteins found in the SNARE complex and destabilizing it to prevent muscle movement. If you can’t frown, you won’t have wrinkles from frowning.
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Makeup

Pramipexole dihydrochloride is something relatively new to the general populous.  The FDA recently released some guidance compliance information as a piece of regulation as the substance floods into modern medicine.  As time marches on, so does medical science.  Pramipexole dihydrochloride has been found to be extremely effective when it comes to wrestles leg syndrome and Parkinson’s disease.  Most commonly, the drug is marketed under the name Mirapex.

Mirapex, the generic brands, and pramipexole dihydrochloride in general is made up firstly of pramipexole.  Pramipexole is a nonergot dopamine agonist that has been found to reduce the effects of early Parkinson’s disease.  Over the course of the past 10 years, pramipexole has become the preferred method of slowing the progression of the horrendous degenerative disorder, of which there is currently no cure.  The medical community is currently trying to tackle other neurological diseases, specifically those without cures, so that relief may be provided for those showing signs of early stages of these diseases.

Hydrochloride, at its very base definition is any hydrochloride formed by the reaction with two molecules of hydrochloric acid.  Combining hydrochloric acid and pramipexole results in the creation of pramipexole dihydrochloride.  Pramipexole dihydrochloride’s mechanism of action when it comes to treatment of neurological disorders is yet unknown!  Studies in animals imply that it can stimulate dopamine receptors in the striatum.  The corpus striatum is the part of your brain that comprises of caudate and lentiform nuclei.  Without this, we lose motor function and other cognitive bits of our body that we take advantage in every day life.
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What is it?

ACE-031 is technically a protein.  It’s categorized in the protein family.  ACE-031 is also called ACVR2B, in many texts.  This protein is currently being tested to see if we can utilize it to build strength in animals and perhaps eventually, in humans.  There have been some promising studies that imply it can be used therapeutically to destroy other proteins and molecules that limit muscle growth and muscle strength.  Since ACE-031 is a human-engineered protein, it’s not actually part of the proteome project.

ACE-031 is actually formed when a bit of the ActRIIB receptor and the antibody are fused together.  This fusion makes a pho version of the ActRIIB that will take down proteins like myostatin and the other types of molecules that prohibit the muscle’s ability to strengthen, regenerate, and grow.  Basically, ACE-031 is used to make muscles not understand that there is a natural period in which we don’t produce muscle mass by blocking out the myostatin, stopping it from communicating with the muscle cells.

Effects

Only in the last decade or so has ACE-031 been tested on humans.  In a 2012 study, it was found to increase muscle mass in postmenopausal women after just a single dosing.  For the purpose of this study, it was determined that all of the subjects were “healthy” and didn’t have any form of surgery in the past few months.  There are various reports and studies proving that the use of ACE-031 drastically increases the muscular growth in animals, specifically in mammals.
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